Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs PDF Free Download

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Description:

Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy-to-digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy.Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way; it illustrates key concepts for ease of retention; and, it poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees.

Key Features:

  • Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents
  • Describes how chemotherapy, targeted therapy, immunotherapy, hormonal therapy, work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities
  • Over 135 highly stylized images and numerous comprehensive tables
  • Covers challenges related to drug development, drug approval and regulatory issues in relation to anticancer treatments
  • All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales
  • Purchase includes access to the ebook for use on most mobile devices or computers

Table of contents :

Cover
Title
Copyright
Contents
Contributors
Preface
Chapter 1: Anticancer Drug Development: An Introduction
Introduction
Pathophysiology of Cancer, Where Cancer Drugs Come From
How Do We Know a Cancer Drug Might Be Useful?
Why Do Cancer Drugs Work at All, Stop Working, or Never Work?
Pharmacokinetics: Action of the Host on an Administered Drug
Limitations to Effective Drug Action
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple choice Questions
Selected References
Chapter 2: Alkylating Agents
Introduction
Nitrogen Mustards
Nitrosoureas
Triazines
Ethylenimines
Platinum Compounds
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 3: Antimetabolites: Hydroxyurea, Pyrimidine and Purine Analogs, and L-Asparaginase
Introduction
Ribonucleotide Reductase Inhibition
Asparaginase
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 4: Antimetabolites: Antifolates
Introduction
Role of Folic Acid in Metabolism
Antifolates and Their Mechanism of Action
Folate Transporters
Intracellular Metabolism of Folate and Antifolates
Absorption and Elimination of Antifolates
Antifolate Adverse Events
Toxicity and Rescue with High-Dose Methotrexate Regimens
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 5: Antimitotics
Introduction
Vinca Alkaloids
Taxanes
Newer Microtubule-Directed Agents
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 6: DNA Repair, Apoptotic Pathways, CDK Inhibitors
Introduction
Topoisomerases: Endogenous Enzymes That Become Agents of DNA Damage
Targeting the DNA Damage Response
Activating Apoptosis: BH3 Mimetics and Beyond
CDK Inhibitors: Targeting the Cell Cycle, Antiapoptotic Proteins, and More
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 7: Epigenetic Modulators
Introduction
Bromodomain Inhibitors
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 8: Differentiating Agents and Microenvironment
Introduction
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 9: Hormonal Therapies Alone and in Combinations for Treatment of Breast Cancer
Introduction
Dedication
Estrogen Receptor in Breast Cancer
Selective Estrogen Receptor Modulators
Aromatase Inhibitors
AIs in Combination with Kinase Inhibitors
Selective Estrogen Receptor Degraders
Ovarian Suppression
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 10: Male Hormonal Therapies
Introduction
Prostate Cancer and Androgens Biosynthesis
Androgen Receptor Biology and Signaling in Prostate Cancer
Therapeutic Strategies for Prostate Cancer
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
References
Chapter 11: Targeted Therapies (Small Molecules)
Introduction
Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor
Vascular Endothelial Growth Factor (VEGF) Receptor
Mitogen-Activated Protein Kinase Pathway
Anaplastic Lymphoma Kinase
B-Cell Receptor-ABL
Isocitrate Dehydrogenase and Ten-Eleven Translocation
Bruton Tyrosine Kinase
Janus Kinase/Signal Transducer and Activator of Transcription
FMS-Like Tyrosine Kinase 3
Type I and Type II Tyrosine Kinase Inhibitors
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
References
Chapter 12: Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents
Introduction
Naked Monoclonal Antibodies
Antibody–Drug Conjugates
Radioimmunoconjugates
Cytokine Therapy
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 13: Immunotherapeutics Including Vaccines, Bispecifics, CAR-T, and Checkpoint Inhibitors
Introduction
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
References
Chapter 14: Multiple Myeloma as a Paradigm for Multi-Targeted Intervention
Introduction
Alkylating Agents
Immunomodulatory Drugs (IMiDs)
Proteasome Inhibitors
Corticosteroids
Antibodies
Other Immune Therapies
Epigenetic Modulators
Other Anti-MM Drugs
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 15: Transplant-Related Agents
Introduction
Drugs Used in Transplant Conditioning Regimens
Drugs Used for Prevention and Treatment of GVHD
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 16: Basic Drug Development with Structural Considerations
Introduction
Survival Endpoints
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 17: Integral Components in Development of Clinical Trials: PK/PD, Statistics, and Principles of Rational Combinatorial Therapies
Introduction
Chapter Summary
Clinical Pearls
Multiple Choice Questions
Answers to Multiple Choice Questions
Selected References
Chapter 18: Drug Approval and Regulatory Issues
Introduction
Chapter Summary
Multiple Choice Questions
Answers to Multiple Choice Questions
References
Index

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